Roger embarks on a time-travel adventure through Space Quest games both past and future. An infomorph of reborn Sludge Vohaul from Space Quest XII: Vohaul’s Revenge II chases him through time in an attempt to finally kill him.

He also visits Space Quest X: Latex Babes of Estros, whose title parodies Infocom’s Leather Goddesses of Phobos, and Space Quest I. In the latter, the graphics and music revert to the style of the original game, and Roger is threatened by a group of monochromatic bikers who consider his 256 colors pretentious.

None of the gameplay takes place in Space Quest IV. The actual Space Quest IV is only seen briefly in the introduction.