It is 1888 in London’s Whitechapel area, where a series of grisly crimes leaves a trail of mutilated female bodies in the East End. The police struggle to make progress as paranoia spreads through the city.

Sherlock Holmes explores the dark alleyways of Whitechapel to follow the trail of the figure the press calls Jack the Ripper. During the investigation, he tries to uncover the motives and identity behind the name.