Razputin “Raz” Aquato, the son of circus performers, runs away from home and sneaks into Whispering Rock Psychic Summer Camp, a government facility disguised as a children’s camp where young psychics train to become Psychonauts. Although he is told he cannot participate without parental consent, he impresses the instructors enough to receive advanced training.

During one session, he sees a disturbing vision of a mad dentist extracting a camper’s brain. When Raz learns the vision was real and that campers are being targeted for their brains, the adult Psychonauts refuse to believe him.

As campers disappear one by one, Raz must go alone to the abandoned asylum across the lake. There, he enters the fractured minds of its residents to gain their help while trying to rescue the people he cares about before the plot reaches its conclusion.